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A previous study found that abnormally up-regulated transferrin and ferritin in the ovaries of naturally aging rats can cause iron-accumulating oxidative stress and inflammatory aging through the NF-B signaling pathway (43)

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Erianin inhibits the production of EVD68 by inducing G2/M blockade (105), thus suggesting the potential application of erianin in antiviral research

The study also showed that alluloses effects dont rely on the typical sweet taste receptors, indicating a unique biological pathway

Relative contraindications requiring careful consideration and enhanced medical supervision include history of pancreatitis, severe gastrointestinal disease including gastroparesis, diabetic retinopathy (requires ophthalmologic monitoring during therapy), severe kidney disease, history of suicidal ideation or severe depression, gallbladder disease or history of cholecystitis, and age under 18 years

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