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1 Proposed regulatory mechanisms between silent mating type information regulation 2 homolog (SIRT1) and AMP-activated protein kinase (AMPK)

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Available under brand names such as Wegovy for weight management and Ozempic for type 2 diabetes, the FDA approved an oral version called the Wegovy pill, providing an alternative to injections

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Understanding GLP-1 Therapy GLP-1 receptor agonists, such as semaglutide, are FDA-approved for managing type 2 diabetes and weight management when combined with diet and exercise

Disclosure of interest: The SECRETO study has been funded by the Academy of Finland under grant numbers 318075 and 322656, Helsinki and Uusimaa Hospital District (TYH2018318), and Sigrid Juselius Foundation