Why Constipation Happens More Often at the Start of Treatment Your gut contains trillions of bacteria that help regulate bowel movements and water absorption
SELECT Trial Investigators
Image credits: Scott Dudelson / Getty Image credits: Scott Dudelson / Getty#14 Heather Gay Heather Gay said she weighed 20 pounds less after taking Ozempic
Substance use disorders An emerging area of interest for GLP-1RAs is their potential role in the treatment of substance use disorders, including alcohol and nicotine dependence.[51] GLP-1 is endogenously produced in the nucleus tractus solitarius of the brainstem and acts as a neuropeptide modulating reward and addiction pathways.[52, 53] GLP-1 receptors are expressed in key regions involved in reinforcement, including the ventral tegmental area and nucleus accumbens, where they modulate glutamatergic signaling, potentially influencing feeding and substance-related behaviors.[53, 54] Though ongoing trials are actively investigating the role of GLP-1RAs in substance use disorders, the current evidence base is constrained by a small number of studies, limited randomized controlled trials, heterogeneity in agents evaluated, and variability in outcome measures.[55] One cohort study of U.S
Typically, individuals with a BMI of 30 or higheror 27 and above with weight-related health conditionsmay qualify for treatment
Innovative studies have demonstrated the feasibility of biodegradable microneedle patches incorporating GLP-1 analogs such as exenatide and liraglutide, achieving sustained glucose-lowering effects in preclinical models
