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The function of famous oncometabolites like 2-hydroxyglutarate, fumarate, or succinate has not been extensively described for the PC microenvironment

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However, only GIP(8-42) exhibited antagonistic properties in vivo in mice reducing the effects of the native agonist, GIP(1-42)

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Muscle loss with GLP-1RAs is probably proportional to the extent of weight loss, and resistance exercise with adequate protein intake is recommended to preserve muscle mass and function