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For women with inherent (known or unknown) genetic aberrancies predisposing to the condition, the association may not be relevant due to additional influences conferred by the environment and lifestyle-induced metabolic changes (i.e., gene/environment interactions)

Abstract Lifestyle changes such as dietary habits, sedentary life and consumption of energy-dense foods that have occurred over the years has led to an epidemic of abdominal obesity, which in turn resulted in dramatic increase in the prevalence of metabolic syndrome (MetS)

Chandrasekar, V

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Those following specific diets, such as vegan or vegetarian, might also benefit, as these diets can lack sufficient B12 sources

2 Methyl-B12 is an essential cofactor in the one-carbon methylation cycle converting homocysteine to methionine, and in the course converting methyl-tetrahydrofolate back to tetrahydrofolate