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The second agent may be a sulfonylurea, SGLT2 inhibitor, or a preferred GLP-1 such as Ozempic or Trulicity

Aquaporins Are One of the Critical Factors in the Disruption of the Skin Barrier in Inflammatory Skin Diseases

Vinogradov IV, Gamidov SI, Gabliya MY, et al

In pulmonary fibrosis studies using bleomycin-induced injury in mice, doses of 2.6-260 g/mL/day administered every other day from day 4-21 reduced inflammatory cell infiltration, decreased interstitial thickness, and reduced TNF- and IL-6 expression

But hunger pangs, cravings, and food noise can all make it extremely hard to eat in a calorie deficit

It is estimated that 130 million Americans currently live with a condition eligible to be treated with a GLP-1 agonist, and that up to 70 million Americans may use a GLP-1 by 2028