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To maintain a balanced gut flora, it is thought to support beneficial microorganisms, compete with pathogens, and restore a healthy gut microbiota

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However, a 57% reduction in renal events was observed compared to those receiving only GLP-1 RAs (114)

Treatment intensification or modification For individuals who do not have CV or renal comorbidities, choice of an antihyperglycemic medication when treatment intensification is required should be based on the individual's priorities, preferences, and comorbidities (see Figure 1 and Table 1) [12]