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Study selection Studies were selected using the PICO (patient/population, intervention, comparison and outcomes) format to include those that studied patients with DM2 (Population), comparing those on one of GLP-1 Ras: Dulaglutide (Trulicity), Exenatide extended release (Bydureon), Exenatide (Byetta), Semaglutide (Ozempic), Semaglutide (Rybelsus), Liraglutide (Victoza), or Lixisenatide (Adlyxin) (Intervention) to patients not on GLP-1 RAs (Comparison), and assessing for all-cause mortality, cardiovascular mortality, and composite endpoint of ventricular and atrial arrhythmias and sudden cardiac death (Outcomes)

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Other factors can also accelerate the depletion, which include: A consistently poor diet lacking essential nutrients

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