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PLoS One (2009) 4(3):e4962

Semaglutide reduced waist circumference by 13.0 cm, reflecting significant fat loss Tirzepatide Tirzepatide is a dual agonist of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors

This variation reflects individual GI sensitivity and circadian differences in appetite hormone expression

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