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Within the nucleus, Pdx1 binds to the insulin promoter, initiating insulin expression and synthesis (Wang et al., 2001

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31,32 In HIVAC, disruptions in autophagy machinery lead to accumulation of abnormal mitochondria independent of viral entry pathways, whereas Highly Active Antiretroviral Therapy (HAART) agents such as azidothymidine and abacavir further exacerbate autophagy defects

Human mesenchymal stem cells efficiently manage oxidative stress