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In clinical trials unfortunately there is a rush to get to the top dose and slowing down dose escalation as an option isnt always built into the protocol

10.1016/j.brainres.2012.03.065 118 ZhaoL.LiH.GaoQ.XuJ.ZhuY.ZhaiM.et al (2021)

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As of May 2024, there are at least 13 major medications available for prescription use