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doi: 10.1038/ki.2014.222

In contrast, MTs without any bound metal (known as apo-MTs or thioneins) possess a mainly disordered molecular structure, which renders them extremely susceptible to proteolytic degradation [29]

Beyond structural matrix effects, GHK-Cu has potent antioxidant activity via SOD and glutathione pathway upregulation, suppresses inflammatory cytokines including TGF-beta and TNF-alpha, and promotes angiogenesis by inducing VEGF and FGF-2 expression