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The logic was straightforward, the clinical use widespread, and the benefits, at least for symptom management, well established

Furthermore, most evidence for cardiovascular event reduction with use of GLP1-RA has been within a general diabetes population, and evidence for patients with moderate to advanced kidney disease has been limited

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The enhancement of Nrf2 transcription with sulforaphane or melatonin could benefit patients with LONG COVID (Post-Acute Sequelae of SARS-CoV-2 or Post-COVID-Syndrome), a significant proportion (approximately 40%) of individuals with COVID-19 experiencing a variety of symptoms (loss of smell and/or taste, fatigue, cough, aching pain, brain fog, insomnia, shortness of breath, and tachycardia) after 12 weeks (Jarrott et al., 2022

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