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Multiagonist unimolecular peptides for obesity and type 2 diabetes: current advances and future directions

New Phytol Cambridge 178:923

doi: 10.1038/nm.4236 98

In the peripheral system, GLP-1R mediates the actions of GLP-1 via the incretin axis, in which stimulation of the GLP-1R with GLP-1 primarily triggers insulin release from islet cells in a glucose-dependent manner and inhibits glucagon secretion from islet cells (110)