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Eight-week-old Bmal1 lox/lox / Pax8-rtTA /LC-1 mice and their Bmal1 lox/lox littermate mice were treated for 2 weeks with DOX at 2 mg/mL in drinking water along with 20mg/mL sucrose to induce the Cre recombinase inactivation of the Bmal1 ( Arntl ) gene

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For a long time, hydrogen peroxide (H 2 O 2 ) was considered as a classic model for oxidative stress, and it can also activate ER stress through modulation of ROS generation ( 2 O 2 has been demonstrated that would increase ROS levels and induce ER stress in a dosage-dependent manner ( 2 O 2

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Reduction in binge eating Compared with placebo or other control treatments, people taking GLP-1RAs generally reported fewer binge-eating-related symptoms

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