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Fortunato F, Martinelli D, Lo Caputo S, Santantonio T, Dattoli V, Lopalco PL, et al

Oxidative stress and mitochondrial damage are inextricably linked to RA development, and our focus was on the mitochondrial regulation of metabolism affecting the disease process of RA

Clinical approach recommendations include starting with the most conservative effective therapy, optimizing tirzepatide dosing before adding other agents, regular monitoring of cardiovascular parameters and metabolic markers, and setting realistic weight loss goals (5-10% initial target)

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