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Arg, Ala, Glu and Tyr were selected as replacements to distinguish the relevance of the charge and size of the side chain and to mimic tyrosine-dependent glutathione transferases 3,18

The gradual dose-escalation approach used with these medications serves to minimize gastrointestinal side effects while achieving therapeutic goals

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Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito

GHK-Cu sits at 340 daltons, meaning it clears fast when administered IM

The expression profile of these genes (Fig