The major obstacles to developing probes that can monitor GSH dynamics include the reaction reversibility and kinetics of the sensing reaction, as well as the high abundance of GSH (110 mM) inside cells
Introduction of exogenous antioxidants combats ferroptosis As IR strongly induces ROS generation and inhibits GPX4 antioxidant activity, introducing exogenous antioxidants is an intuitive anti-ferroptosis strategy
Cytoprotective effects against viruses like SARS-CoV-2 could be enhanced by sulforaphane, an isothiocyanate abundant in cruciferous vegetables, since sulforaphane has been found to be a powerful activator of the Nrf2 pathway by increasing Nrf2-regulated cellular antioxidant response such as induction of NAD(P)H: quinone oxidoreductase 1, glutamate-cysteine ligase (-glutamyl cysteine synthetase) and glutathione (Theodore et al., 2008
author reply, 124-5
P = 0.026) but not for disease-free survival of 140 patients who achieved complete remission (CR)
Poor bioavailability of proanthocyanidin polymers, especially those of plant origin, which may be highly digested by intestinal microorganisms, has also made the intestinal metabolism of proanthocyanidins a hot research topic 79
