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Likewise, the central histamine system in the brain is mediated via G-protein-coupled H1-H4 receptors and also appears to be involved in additional functions like arousal, control of pituitary hormone secretion, suppression of eating and cognitive functions [182]

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Another study using an identical sham-controlled design, but with iTBS cerebellum , in 16 patients found a small but significant improvement in the severity and quality of life scores, but no changes in the cortical neurophysiological parameters [252]