In addition, previous studies have shown that administration of Exendin-4 may increase patients anxiety, which may exacerbate the anxiety of heroin withdrawal patients after medication, making it difficult for them to tolerate this anxiety and give up continuing medication or develop into depression, which may limit the development of GLP-1 analogs [27]
(PubMed) Brooks MJ, Post EM
Abnormal copper homeostasis: mechanisms and roles in neurodegeneration
Gallbladder-related issues such as gallstones have also been reported
For example, the NMDAR antagonist phencyclidine (PCP) can induce hyperlocomotion and PPI deficits (Shirai et al., 2012
Why this matters: Tirzepatide alone already very powerful (15-22%) May already be optimizing GIP/GLP-1 pathways maximally Adding amylin might only add 2-5% more weight loss But could significantly increase side effects Risk-benefit ratio unknown Contrast with CagriSema: CagriSema: Extensively studied, Phase 3 trials, known safety Tirzepatide + cagrilintide: Zero studies, no safety data, speculative Learn about evidence-based approaches at SeekPeptides - explore best peptides for weight loss and best peptide stack for weight loss
