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The Phase 2 trial published in the New England Journal of Medicine showed up to 24.2% weight loss at 48 weeks

The ASRM system does not correlate well with the symptoms of pain and dyspareunia or infertility

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Vitamin B12 also upregulates brain-derived neurotrophic factor (BDNF) and increases nerve conduction velocity, which may reflect part of the regeneration process and brain plasticity [32]

Metabolic adaptation, inconsistent dosing, dietary changes, or the natural plateau that many users experience can all reduce the apparent effectiveness

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