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HER2 heterogeneity has been reported in up to 40% of breast cancers

(Those are not direct comparisons, as the drug were not evaluated in head-to-head clinical trials.) Nausea, constipation and diarrhea were among the side effects of retatrutide they are often seen with GLP-1 drugs

No rapid fat loss yetsignificant fat reduction occurs over several months

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In terms of its effects, it appears to impact drinking in ways (though not necessarily mechanisms) similar to naltrexone (FDA-approved) and topiramate (prescribed off label for alcohol use disorder), which have a greater effect in reducing intensity of drinking on drinking days relative to their effects on whether someone drinks at all (i.e., abstinent days) although all of them do increase abstinent days to some degree on average)