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Despite encouraging preclinical evidence, challenges remain regarding structural complexity, bioavailability, and clinical translation

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Dissolve the 100mg lyophilized powder in sterile water to the desired concentration, typically 5-50 mg/mL depending on the application, by adding water slowly and swirling gently until the characteristic blue color is uniform throughout the solution with no undissolved particles

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HF-SAAR feeding increased 13 C-labeling from glucose in liver methionine in both WT and liver PSAT1 KO mice (Fig