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In acute respiratory distress syndrome, the shedding of the epithelial glycocalyx contributes to the development and progression of lung injury, including excessive alveolar permeability, disruption of surfactant function, greater bacterial virulence, and impaired epithelial cell repair (44)

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The use of dose-adjusted DOACs in the subgroup of patients with AFib in the pivotal RCTs did not result in a significant interaction between dose adjustment and therapeutic effects of DOACs with respect to the primary clinical outcomes

The clinical translation of copper-targeted therapies faces challenges, including off-target effects, systemic toxicity and drug resistance (194)

Our work provides an understanding of how age-associated cognitive decline in older humans is linked to glutathione deficiency, increased oxidative stress, mitochondrial dysfunction, abnormal glucose metabolism and insulin resistance, inflammation and low levels of neurotrophic or neuron-supporting factors, and that supplementing GlyNAC reverses these defects and improves cognition. Human studies only permit measurements at the whole-body level, so in this study the researchers studied mice to investigate defects directly in the aging brain