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In the class-level analysis, tirzepatide significantly reduced MACE (HR 0.79, 95% CI 0.690.91), CV mortality (HR 0.77, 95% CI 0.660.90), all-cause mortality (HR 0.74, 95% CI 0.650.83), non-fatal MI (HR 0.77, 95% CI 0.610.97), and non-fatal stroke (HR 0.79, 95% CI 0.640.97) compared to placebo

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Of patients treated with Skyrizi, 87% achieved 90% clearance in the PASI at week 52 compared to 57% of those administered Cosentyx

A network meta-analysis found that adverse events were more frequent with retatrutide (relative risk 4.10) compared to tirzepatide (relative risk 2.78)