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Marquez-Garcia B, Shaw D, Cooper JW, Karpinska B, Quain MD, Makgopa EM, Kunert K, Foyer CH

87 Singlet electrons reduce oxygen molecules, forming the highly unstable and reactive superoxide, which can damage cellular components (Figure 1)

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The two-receptor approach is studied because GHRH and GHS-R1a signaling activate complementary but distinct intracellular pathways GHRHR primarily through Gs/cAMP/PKA, GHS-R1a primarily through Gq/PLC/IP3/Ca making the dual-agonist approach a useful research tool for studying somatotrope cell biology comprehensively

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