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This is consistent with the lowered reaction rate for the S59C mutant observed in bulk

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Gender differences were observed in numerous aspects of the pharmacology of opioids, including a higher sensitivity to antinociceptive properties ( Conclusion To the best of our knowledge, in this study for the first time, we found that the selective dopamine agonist ropinirole reduces the expression, reinstatement, and morphine withdrawal symptoms and accelerates the extinction of morphine CPP

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Eur J Biochem 267:49124916 Franco R, Schoneveld OJ, Pappa A, Panayiotidis MI (2007) The central role of glutathione in the pathophysiology of human diseases