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Differences in gut metabolites and microbial composition and functions between Egyptian and U.S

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The median time to onset of any-grade hepatic events (29.0 d), diarrhea/colitis (63.0 d), dermatitis/rash (144.0 d), and endocrine events (113.0 d) for participants who received durvalumab monotherapy in our study occurred earlier than in a real-world study of atezolizumab plus bevacizumab in advanced HCC, where the median time to onset of any-grade hepatic, gastrointestinal, dermatologic, and endocrine events was 96.0, 124.0, 168.0, and 133.0 days, respectively

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To satisfy their high glycolytic demands, cancer cells have increased NAD + levels and an upregulated NAD + salvage biosynthesis pathway, the main source of NAD + in cells