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Taylor WJ, Fransen J, Jansen TL, Dalbeth N, Schumacher HR, Brown M, Louthrenoo W, Vazquez-Mellado J, Eliseev M, McCarthy G, Stamp LK, Perez-Ruiz F, Sivera F, Ea HK, Gerritsen M, Scire C, Cavagna L, Lin C, Chou YY, Tausche AK, Vargas-Santos AB, Janssen M, Chen JH, Slot O, Cimmino MA, Uhlig T, Neogi T

For patients dealing with photodamage or hyperpigmentation, GHK-Cu reduces both by addressing the oxidative stress and inflammatory processes that drive them

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Methods: Authors used a computer-based gene profiling tool, The Connectivity Map, to identify a number of human genes regulated by GHK, relevant to regulation of cell differentiation, apoptosis and stem cell function

NAD + biosynthetic pathways differ widely across tissues and display tissue-specific preference for different NAD + precursors