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GLP-1 RAs offer a potential benefit in these patients due to their pleiotropic effects, which go beyond simple glycemic control

MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling

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DSIP also modulates the hypothalamic-pituitary-adrenal (HPA) axis, which controls the release of stress hormones like cortisol and adrenocorticotropic hormone (ACTH)

While there are a myriad of benefits from intense exercise, it is technically a physiological stressor, as it creates oxidation, aka chemical stress, within the body systems