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The body produces it in bursts after meals, and it is quickly degraded

Oral supplementation with a combination of L-citrulline and L-arginine rapidly increases plasma L-arginine concentration and enhances no bioavailability

Based on results from all three phases of the present study, it is evident that L-citrulline supplementation impacted extracellular arginine concentration and the subsequent intracellular arginine synthesis based on the responses we observed in nitrite and NOx concentrations

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However, our team has found that most patients have great success taking their dose first thing in the morning on an empty stomach, about 30-60 minutes before breakfast