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Hybrid systems, comprising polymer shells and inorganic cores, further complicate safety evaluation due to potential synergistic toxicity from acidic degradation products, enhanced inorganic ion release, and unanticipated immune activation [484]
The compound exhibited notable cytotoxicity in cells with elevated DT-diaphorase expression and enabled the simultaneous monitoring of the in vitro drug activation process
Another large study showed that using GLP-1s may help prevent immune-related diseases in people with diabetes or obesity People with diabetes who took GLP-1 drugs had a lower chance of developing rheumatoid arthritis, gout, and osteoarthritis compared to people on other diabetes medications
There are only few studies trying to answer these questions
