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Melanocytes become smaller, and the nests of cells diminish in size and are separated by increasing amounts of dermal collagen

This view entails that CFAS-Ds, even when due to medical disease (e.g., cancer), are the consequence of psychosocial and biological factors and negative cognitions (14)

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Fine Lines (Week 6+): Fine line improvement takes longer than dark circle reduction, typically visible after 6-8 weeks of consistent use