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Stearoyl-CoA desaturase 1 (SCD1), the rate-limiting enzyme in MUFA synthesis, enhances cellular resistance to ferroptosis by modulating the PUFA/MUFA ratio ( 2.2.2 Dual-pathway activation of lipid peroxidation Lethal lipid peroxidation is triggered synergistically by enzymatic and non-enzymatic pathways

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Therefore, we conclude our crystal structure represents a physiologically relevant snapshot of GLP-1R in an inactive peptide-free state