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Metformin has been widely studied for its ability to improve insulin sensitivity and support overall metabolic health

The combination of anti-cancer medications improves efficacy in comparison to monotherapy because it targets important pathways in a manner that is typically additive or synergistic

Considering these preclinical studies, an ASO directed at PNPLA3, called ION839 (AZD 2693), is currently in phase I clinical investigation in patients with MASH carrying the I148M risk alleles of PNPLA3 (NCT04483947)

However, if these shifts happen too abruptly or become severely imbalanced, symptoms like hot flashes, fatigue, and anxiety can intensify

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