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B12 adequacy is directly relevant here since B12 deficiency independently causes cognitive symptoms and mood disturbance, which is another reason the B12-containing formulation is preferred for long-term use

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A NASH mouse study confirmed that using vitamin A-modified liposomes to target hepatic stellate cells (HSCs) and deliver SREBP2-siRNA or anti-miR-33a can reduce cholesterol accumulation in activated HSCs, thereby significantly improving liver fibrosis

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