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Reduce the dose by 50% and extend the titration schedule
Perimenopause & Menopause Support : In one study involving women taking HRT, those who combined GLP-1 therapy with hormone therapy experienced approximately 30% more weight loss than those using GLP-1s alone (8)
[DOI] [PubMed] [Google Scholar] 401.Wakeman M
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A key reason for the success of its Zepbound drug is its status as a "dual agonist." Wegovy targets only GLP-1 receptors, whereas tirzepatide (aka Zebound) targets both GLP-1 and GIP receptors, leading to greater overall weight loss
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