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To prospectively test the ability of this model to design new peptides with specific activity, we used a simple optimization strategy to design 15 peptides, five in each of three different activity profiles: selective potency at GCGR, selective potency at GLP-1R or high-potency at both receptors

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Protective effects of catalpol on diabetes mellitus-induced male reproductive damage via suppression of the AGEs/RAGE/Nox4 signaling pathway

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This side effect occurs as your body adjusts to the medication, which works to regulate appetite and blood sugar levels

There are no randomized controlled trials (RCTs) exploring this question, and only a small number of observational studies have assessed outcomes after treatment switch [13, 14]