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No confirmed tumor promotion has been documented in published animal studies, but the theoretical risk remains a cited contraindication for individuals with active cancer or a cancer history

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Furthermore, cellular senescence and the SASP exacerbate chronic inflammation and glial dysfunction, with sex differences and lipid metabolism playing modulating roles

[40]Location in patent: experimental part Staab, Claudia A

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But because human data support the interaction, caution and monitoring are appropriate