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Combination therapies Rather than relying on a single compound to do everything, the field is increasingly moving toward rational combinations

However, while in microglia, inflammasome induction under high cholesterol levels leads to a neuroprotective phenotype with upregulated phagocytosis, in SH-SY5Y neuronal cells the activation of the inflammasome increases pyroptotic death and is linked to enhanced mitochondrial oxidative stress

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More recently, combination agents have also begun to gain momentum, with one, tirzepatide (Mounjaro