Simultaneously, ROS disrupts insulin signaling in peripheral tissues by promoting IRS-1 serine phosphorylation and degrading phosphatidylinositol-3-kinase (PI3K)/Akt activation, leading to insulin resistance (Papaetis et al., 2025)
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However, chloroquine is shown to result in cardiotoxicity, often in the form of restricted or dilated cardiomyopathy or conduction system abnormalities
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