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Furthermore, we show that p53 phosphorylation enhances the affinity for both FOXO4 and FOXO4-DRI

81,82,114 Although lowering glucose is generally ineffective for preventing stroke and cognitive impairment, 113 some drugs do provide these benefits in addition to controlling glucose levels

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This is a potentially lethal complication of metformin therapy that typically occurs when renal dysfunction results in very high blood metformin levels, which inhibit mitochondrial function resulting in the overproduction of lactate (53)

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