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Bosco, E., Hsueh, L., McConeghy, K

Pancreatitis has been reported in Zepbound clinical trials

When the basement membrane (the fibrous layer between cells and adjacent connective tissue) becomes enriched in laminin-332, melanocytes attach to that protein instead of the normal laminin-211 (via an integrin receptor instead of dystroglycan)

On the other hand, a strength trainer could gain weight from building muscle, since muscle weighs more than fat, even though they are actually becoming leaner and healthier

299 For example, gut microbiota can influence host glucose metabolism and hormone production via the production of several metabolites like short-chain fatty acids (SCFAs, mainly including acetate, propionate, and butyrate) and bile acids

Alternative weight management strategies during this transition period should be explored