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For example, reduced plasma glutathione levels have been shown to represent an increased risk for cardiovascular disease, iv And the primary cause of the neurodegeneration that leads to Parkinsons disease

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In vivo, [13C5]-glutamine infusion in mice with subcutaneous xenograft tumours shows higher glutamine labelling in the TCA cycles of PIK3CA-mutant tumours than in PIK3CA-WT tumours (124)

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