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A meta-analysis of 77 RCTs involving 50,820 patients with T2DM found that compared with placebo, lifestyle modification, or active anti-diabetic drugs, SGLT2is were associated with a significantly higher risk of genital infections (RR, 3.30
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Experts warn that a lack of data does not mean a lack of risk
doi: 10.1371/journal.pone.0181350 111 LeTNZhouQPCobosIZhangSZagozewskiJJaponiSet al
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Its primary mechanisms involve tissue healing through enhanced angiogenesis, growth factor modulation, and nitric oxide system interaction
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