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First, Id like to say that I prefer the term MTHFR gene variation rather than mutation. The word mutation makes it sound like theres something wrong with the person, while variation is more empowering and in my opinion, also more accurate

The article notes that underfilling or overfilling alters dose accuracy, which is exactly why the pharmacy specifies the ratio for its own formulation and documents it on the label

However, its not primarily a neuro-modulator like Tesofensine

10.1074/jbc.M109.020107 37 DixonD

For each system, a citation matrix was constructed, with rows representing unique primary studies and columns representing the included meta-analyses