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The major enzyme superfamilies comprise cytochrome P450 monooxygenases (P450s), glutathione S-transferases (GSTs), carboxylesterases (COEs), ATP-binding cassette (ABC) transporters, and UDP-glycosyltransferases (UGTs) [5, 26, 36-39] (Figure 2)

SCFAs activate GPCRs (GPR43/41) and inhibit histone deacetylases (HDAC), promoting regulatory T-cell (Treg) differentiation while suppressing Th17 cell polarization within the joint, thereby restoring immune homeostasis and reducing pro-inflammatory cytokine release

Patients should not purchase products claiming to contain retatrutide from unregulated sources, as these carry serious safety risks including counterfeit or incorrectly dosed products

10.1016/j.semcdb.2012.03.017 117 ZhangG.YaoQ.LongC.YiP.SongJ.WuL.et al (2025)