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Moreover, the increase in reactive oxygen species (ROS) and reactive nitrogen species (RNS) in endothelial cells due to systemic inflammation might alter claudins and occludins, which are critical structural components of the BBB

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( / and ApoE / mice on a Western diet (WD) were given daily injections of liraglutide or semaglutide or vehicle control for 12 to 17 weeks (12 to 14 weeks in ApoE / mice and 17 weeks in LDLr / mice)

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Beta-N-methylamino-L-alanine (BMAA), a neurotoxin made by certain bacteria may play an important role in the development of ALS