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Although the general mechanisms of APAP-induced liver injury appear to be very similar in the 2 substrains [132], the risk for experimental design is that there is a mismatch in the substrains between WT and KO mice, which can lead to misinterpretation of the data

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doi: 10.1161/01.cir.94.7.1629

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doi: 10.2174/1871530320666200729144430 89