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[DOI] [PubMed] [Google Scholar] 215.Hu W, Ru Z, Zhou Y, Xiao W, Sun R, Zhang S, et al
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-syn aggregation leads to increased iron deposition and ferroptosis in PD mice, while MT1 knockout reduces the resistance of neurons to ferroptosis by inhibiting the SIRT1/Nrf2/HO-1/GPX4 pathway and inhibiting the expression of ferritin FTH1, resulting in more ferrous ion release, which further leads to more DA neuron loss and severe dyskinesia